Hyssop reportedly originated in the area around the Black Sea in central Asia and today is widely cultivated in other arid regions, partly because it thrives even in the most desolate soils. Hyssop’s fragrant flowers and leaves are used as medicine.

Hyssop has been used in connection with the following conditions: asthma, colic, common cold/pharyngitis, cough.

Mentioned in the Bible, Hyssop (a member of the mint family) contains several antiviral compounds and is useful in treating herpes.

Hyssop appears to be effective as an expectorant used for coughs and colds. It may also be helpful in soothing the respiratory tract, which often becomes irritated during bouts of the common cold.

Hyssop infusion (tea) contains a compound called MAR-10. Studies have shown that in test tubes, this compound inhibits HIV replication with no toxicity to healthy cells. It's too early to know for sure, but there are no reports showing that Hyssop causes any harm, even in large doses. Just mix a few teaspoons of dried Hyssop into any herb tea.

Historical or traditional use (may or may not be supported by scientific studies): The most common uses of hyssop in traditional herbalism have been to relieve chest congestion and coughs, to soothe sore throats, and to act as a mild sedative.1 Some herbalists consider it stronger for relieving gas or intestinal cramping than for easing a cough.2 In addition to using hyssop for the above conditions, early 20th century Eclectic physicians (doctors who recommended herbs) in the United States used the herb topically to soothe burned skin.3

Active constituents: Due to the presence of volatile oil constituents in hyssop, it may provide relief for mild irritations of the upper respiratory tract that accompany the common cold. The expectorant action of hyssop’s volatile oil may partially explain its traditional use for coughs, asthma, and bronchitis.4 The volatile oils are also thought to contribute to hyssop’s carminative actions and use for mild cramping and discomfort in the digestive tract. The German Commission E has not approved hyssop for any medical indication.5 Test tube studies have found that certain fractions of hyssop (one being a polysaccharide designated as MAR-10) may inhibit the activity of the human immunodeficiency virus (HIV).6 7 Yet, there have been no studies in humans to determine whether hyssop or any of its constituents are effective in treating HIV infection or AIDS.

Hyssop may be taken as a tea or tincture. The tea is prepared by infusing 2–3 teaspoons of herb in one cup (250 ml) of hot water for ten to fifteen minutes. Three cups can be drunk per day. Alternatively, 1–4 ml of tincture can be taken three times per day.8 If hyssop is being used to help soothe a sore throat, gargle with the tea or tincture before swallowing. The essential oil should never be used at a level higher than 1–2 drops per day internally, though more can be used topically on unbroken skin. One teaspoon (5 grams) of hyssop herb steeped in 1 cup (250 ml) hot water in a closed vessel for 15–20 minutes, then given in sips from a bottle over a period of 2–3 hours, may help calm colic.

Side effects or interactions: Tea and tincture of hyssop are unlikely to cause adverse effects.9 Although, the volatile oil, particularly its constituent pinocamphone, has been reported to cause seizures in laboratory animals as well as in humans when taking more than 10 drops in a day or a child taking 2–3 drops over several days.10 For this reason, the volatile oil should be used with extreme caution and is not recommended for those with epilepsy or any other seizure disorder. The herb is not recommended during pregnancy.11

At the time of writing, there were no well-known drug interactions with hyssop.

References:
1-3. Castleman M., The Healing Herbs. New York: Bantam, 1991, 323–7.
2. Weiss RF., Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1985, 206.
4. Gruenwald J, Brendler T, Jaenicke C (eds)., PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 2000, 414–5.
5-9. Blumenthal M, Busse WR, Goldberg A, et al. (eds)., The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 338–9.
6. Gollapudi S, Sharma HA, Aggarwal S, et al., Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1. Biochem Biophys Res Commun 1995;210:145–51.
7. Kreis W, Kaplan MH, Freeman J, et al., Inhibition of HIV replication by Hyssop officinalis extracts. Antiviral Res 1990;14:323–37.
8. Hoffmann D., The New Holistic Herbal. New York: Barnes & Noble, 1990, 207.
10. Tisserand R, Balacs T., Essential Oil Safety: A Guide for Health Care Professionals. Edinburgh: Churchill Livingstone, 1995, 67.
11. McGuffin M, Hobbs C, Upton R, Goldberg A (eds)., American Herbal Product Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 63.
 

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