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Atractylodes has been shown to act on the stomach and spleen. It can be used to stimulate appetite, and stop vomiting and diarrhea. It is a diuretic and has been used for edema, fatigue, spontaneous sweating, fever and chills. It has been used in pregnancy for morning sickness and restless fetus."

Pharmaceutical name: Rhizoma Atractylodis Macrocephalae
Properties and Actions: Stomachic, appetite stimulant, diuretic, diaphoretic.
Properties: bitter, sweet, warm. Channels entered: Spleen, Stomach
Functions and clinical use: Tonifies the Spleen and benefits the Qi: used for Spleen or Stomach Deficiency patterns with such symptoms as diarrhea, fatigue. lack of appetite, and vomiting. Strengthens the Spleen and dries Dampness: used for digestive dysfunctions from the Spleen Yang failing to rise, with loss of its transforming ability and subsequent accumulation of Dampness. It is also used for edema and decreased urination in Deficient Spleen patterns. In addition, it is an auxiliary herb for Damp Painful Obstruction. Stabilizes the Exterior and stops sweating: used for spontaneous sweating from Deficient Qi.
Pharmacological and clinical research: Urinary effect: in many animal experiments Rhizoma Atractylodes Macrocephalae (Bai Zhu) has demonstrated a significant and prolonged diuretic eitect. When it was given by gastric lavage in doses of 1-3 g/kg, there was a two to sixfold increase in urinary output that was usually sustained for six to seven hours. The excretion of sodium is even greater than that of water. This herb does not seem to affect the function of ADH. The reports of the few experiments testing the diuretic effect of this herb in humans have been equivocal.
Endocrine effect: in many experiments on animals, Rhizoma Atractylodes Macrocephalae (Bai Zhu) increases the assimilation of glucose and lowers plasma glucose levels.
Hematologic effect: gastric lavage with decoctions of Rhizoma Atractylodes Macrocephalae (Bai Zhu) mildly elevated the prothrombin times in rats. When healthy volunteers took a tablespoon of a 1:20 solution of the decoction of this herb three times a day for four days, there was a significant prolongation of the prothrombin time. This did not return to normal until 10 days after administration was stopped. Alcohol-extracted preparations had a weaker effect.
Effect on endurance: when mice were given decoctions of Rhizoma Atractylodes Macrocephalae (Bai Zhu) orally in doses of 6 g/kg for a month there was an increase in weight and endurance (as measured by the swimming test).
Toxicity: The LD50 for peritoneal injection of Rhizoma Atractylodes Macrocephalae (Bai Zhu) is 13.3 g/kg. When rats were fed decoctions of the herb in doses of 0.5 g/kg for one to two months, no toxic symptoms developed. However, a mild lymphopenia and anemia did develop without any signs of damage to the brain, heart, or liver.

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